{"id":70,"date":"2026-11-06T09:06:25","date_gmt":"2026-11-06T09:06:25","guid":{"rendered":"https:\/\/healthcare.hibisports.com\/?p=70"},"modified":"2026-11-06T09:06:25","modified_gmt":"2026-11-06T09:06:25","slug":"this-experimental-pill-mimics-a-hormone-produced-during-intense-exercise","status":"publish","type":"post","link":"https:\/\/healthcare.hibisports.com\/?p=70","title":{"rendered":"This Experimental Pill Mimics a Hormone Produced During Intense Exercise"},"content":{"rendered":"<div id=\"health-sc-page_1-0\" class=\"comp health-sc-page mntl-sc-page mntl-block structured-content article-content expert-content right-rail__offset lock-journey\" data-sc-sticky-offset=\"60\" data-sc-ad-label-height=\"24\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"4\" data-sc-content-positions=\"[400, 1400, 1400, 1700, 2000, 2200, 2400, 2600, 2800]\" data-bind-scroll-on-start=\"true\">\n<div id=\"health-sc-block-callout--takeaway_1-0\" class=\"comp health-sc-block-callout--takeaway health-sc-block-callout-base mntl-sc-block-callout mntl-block theme-takeaway theme-takeaway\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<h3 id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key Takeaways<\/h3>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block expert-content\">\n<ul>\n<li>ENV-308 is an experimental pill designed to preserve muscle mass and support weight maintenance after stopping GLP-1 medications.<\/li>\n<li>In Phase 1 trials, ENV-308 was well tolerated, showed rapid reductions in leptin levels, and prevented weight regain in animal studies.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> An experimental pill<strong> <\/strong>could eventually help people maintain their weight and muscle after stopping GLP-1 medications.<span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-1\" tabindex=\"0\">1<\/span><span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-1\" tabindex=\"0\">1<\/span>\n<\/p>\n<div id=\"mntl-sc-block_3-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The daily oral pill aims to preserve lean muscle and mimic the effects of a hormone that can suppress appetite. However, clinical trials are still ongoing,<strong> <\/strong>and most of the benefits have only been observed in animal studies.\n<\/p>\n<div id=\"mntl-sc-block_5-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-how-env-308-may-help-control-appetite\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> How ENV-308 May Help Control Appetite <\/span> <\/h2>\n<p id=\"mntl-sc-block_7-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Created by the biotechnology company Enveda, ENV-308 is the first drug in human trials to mimic the effects of <em>N<\/em>-lactoyl-phenylalanine (Lac-Phe), a metabolite induced by intense physical exercise.<span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-1\" tabindex=\"0\">1<\/span><span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-8\" tabindex=\"0\">2<\/span> The molecule suppresses appetite and regulates<strong> <\/strong>the weight-loss effects of <a class=\"recommendation-inline-link\" href=\"https:\/\/www.verywellhealth.com\/metformin-how-to-prevent-side-effects-1087301\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">metformin<\/a>, a medication commonly used to treat type 2 diabetes.<span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-2\" tabindex=\"0\">3<\/span>\n<\/p>\n<div id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\">\n<div id=\"mm-ads-native_1-0\" class=\"comp mm-ads-native \" style=\"--native-ad-height: auto\" data-right-rail-index=\"1\">\n<div id=\"mm-ads-native__adunit_1-0\" class=\"comp mm-ads-native__adunit mm-ads-gpt-dynamic-adunit mm-ads-gpt-adunit scads-to-load gpt native js-immediate-ad js-immediate-ad-loaded\">\n<div id=\"native\" class=\"wrapper\" data-type=\"native\" data-pos=\"native\" data-priority=\"4\" data-sizes=\"[[1, 3],&quot;fluid&quot;]\" data-rtb=\"false\" data-wait-for-third-party=\"false\" data-targeting=\"{}\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cLac-Phe has been implicated in appetite regulation and metabolic effects,\u201d <a href=\"https:\/\/nyulangone.org\/doctors\/1104010511\/holly-f-lofton\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Holly Lofton, MD<\/a>, the director of the medical weight management program at the NYU Grossman School of Medicine, told Verywell. \u201cBut the natural molecule that we make isn\u2019t staying around our bodies long enough to really function conveniently as a drug. So that\u2019s why they\u2019re replicating it in a lab to try to develop this ENV-308.\u201d\n<\/p>\n<div id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_11-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The phase 1 trial enrolled 88 healthy adults and evaluated ENV-308\u2019s safety and tolerability. The trial also measured the drug\u2019s <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/leptin-8683745\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">impact on leptin<\/a>, a hormone that normally reduces food intake and increases energy expenditure. However, people with obesity could develop chronically elevated leptin levels<strong>,<\/strong> and the brain can stop responding to it, which is known as <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/leptin-resistance-8684009\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"2\" rel=\"noopener noreferrer\">leptin resistance<\/a>.<span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-1\" tabindex=\"0\">1<\/span>\n<\/p>\n<div id=\"mntl-sc-block_12-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Phase 1 found that ENV-308 caused rapid reductions in leptin levels, with the greatest decreases occurring in people with the highest leptin levels.<span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-5\" tabindex=\"0\">4<\/span> This suggests that the drug is improving leptin sensitivity, potentially making the hormone more effective at regulating food intake and body mass.\n<\/p>\n<div id=\"mntl-sc-block_14-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-early-trial-did-not-find-common-gi-side-effects\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> Early Trial Did Not Find Common GI Side Effects <\/span> <\/h2>\n<p id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> In animal studies, ENV-308 also prevented weight regain and <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/glp-1-drug-combo-preserve-muscle-11924117\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">preserved lean muscle mass<\/a> during weight loss, even after GLP-1 treatment was discontinued.<span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-1\" tabindex=\"0\">1<\/span>\n<\/p>\n<div id=\"mntl-sc-block_17-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_18-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cThat\u2019s going to be really important for people who can\u2019t actively exercise during weight loss. Do we want everybody to eat less and move more? Absolutely. But what about a bilateral amputee who doesn\u2019t have legs? This could be the start of offering individualized medications based on what the patient needs,\u201d said <a href=\"https:\/\/www.uvahealth.com\/providers\/Catherine-Varney-1861700239\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Catherine Varney, DO<\/a>, a physician in family medicine and obesity medicine at UVA Health and&nbsp;associate professor of family medicine at the University of Virginia School of Medicine.\n<\/p>\n<div id=\"mntl-sc-block_19-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_20-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> It\u2019s unclear whether ENV-308 will preserve muscle and prevent weight regain in humans, but these effects will be examined in the Phase 2 trial.\n<\/p>\n<div id=\"mntl-sc-block_21-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_22-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Enveda, the pharmaceutical company developing ENV-308, said<strong> <\/strong>the experimental drug could offer additional benefits, noting that adults who took it did not experience gastrointestinal issues such as nausea or vomiting, which are common side effects of GLP-1.<span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-3\" tabindex=\"0\">5<\/span>\n<\/p>\n<div id=\"mntl-sc-block_23-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_24-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Varney noted that more research is needed to confirm whether gastrointestinal side effects could occur with ENV-308.\n<\/p>\n<div id=\"mntl-sc-block_25-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<div id=\"health-sc-block-spotlight--mid-circ_1-0\" class=\"comp health-sc-block-spotlight--mid-circ mntl-sc-block-spotlight--mid-circ mntl-block theme-mid-circ theme-mid-circ\" data-use-proximity=\"true\">\n<h2 id=\"midcirc__heading_1-0\" class=\"comp midcirc__heading mntl-text-block\">Related Stories<\/h2>\n<div id=\"midcirc__card-list_1-0\" class=\"comp midcirc__card-list mntl-block\"><a href=\"https:\/\/www.verywellhealth.com\/glp-1-drugs-blood-pressure-11979086\" rel=\"nocaes\" data-card-index=\"0\" data-click-tracked=\"false\" id=\"midcirc-card_1-0\" class=\"midcirc-card mntl-midcirc-card mntl-text-link \" data-tracking-container=\"true\"><\/p>\n<div id=\"midcirc-card__title_1-0\" class=\"comp midcirc-card__title mntl-text-block\">New Research Shows GLP-1 Drugs May Help Reduce Blood Pressure<\/div>\n<div id=\"midcirc-card__image-wrapper_1-0\" class=\"comp midcirc-card__image-wrapper mntl-block\">\n<div class=\"midcirc-card__image mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\" style=\"padding-bottom:66.6%;\">\n<img data-src=\"https:\/\/www.verywellhealth.com\/thmb\/JA6dov_zpWD161B-RfXeeqgylIY=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-2277072224-253694d5d5264cc6b2ba7d55e3d92845.jpg\" width=\"300\" height=\"200\" alt=\"Table with medicine blister packs water glass and GLP-1\" class=\" universal-image__image lazyloadwait\"><br \/>\n<noscript><br \/>\n<img\nsrc=\"https:\/\/www.verywellhealth.com\/thmb\/JA6dov_zpWD161B-RfXeeqgylIY=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-2277072224-253694d5d5264cc6b2ba7d55e3d92845.jpg\"\nwidth=\"300\"\nheight=\"200\"\nclass=\"img--noscript universal-image__image\"\nalt=\"Table with medicine blister packs water glass and GLP-1\"\n\/><br \/>\n<\/noscript>\n<\/div>\n<\/div>\n<\/div>\n<p><\/a><br \/>\n<a href=\"https:\/\/www.verywellhealth.com\/benefits-of-metformin-beyond-blood-sugar-12177130\" rel=\"nocaes\" data-card-index=\"1\" data-click-tracked=\"false\" id=\"midcirc-card_2-0\" class=\"midcirc-card mntl-midcirc-card mntl-text-link \" data-tracking-container=\"true\"><\/p>\n<div id=\"midcirc-card__title_2-0\" class=\"comp midcirc-card__title mntl-text-block\">3 Health Benefits of Metformin Beyond Blood Sugar, According to a PharmD<\/div>\n<div id=\"midcirc-card__image-wrapper_2-0\" class=\"comp midcirc-card__image-wrapper mntl-block\">\n<div class=\"midcirc-card__image mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\" style=\"padding-bottom:66.6%;\">\n<img data-src=\"https:\/\/www.verywellhealth.com\/thmb\/HGL9w2QjTTCru7ZuTBJ1jzPmDo8=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-2219773997-1da4b366f2b845bc85578e21ce65f56b.jpg\" width=\"300\" height=\"200\" alt=\"Person sitting on couch holding medication pills and glass of water\" class=\" universal-image__image lazyloadwait\"><br \/>\n<noscript><br \/>\n<img\nsrc=\"https:\/\/www.verywellhealth.com\/thmb\/HGL9w2QjTTCru7ZuTBJ1jzPmDo8=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-2219773997-1da4b366f2b845bc85578e21ce65f56b.jpg\"\nwidth=\"300\"\nheight=\"200\"\nclass=\"img--noscript universal-image__image\"\nalt=\"Person sitting on couch holding medication pills and glass of water\"\n\/><br \/>\n<\/noscript>\n<\/div>\n<\/div>\n<\/div>\n<p><\/a><\/div>\n<\/div>\n<div id=\"mntl-sc-block_27-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-env-308-doesnt-have-the-same-weight-loss-effect-as-glp-1\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_28-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> ENV-308 Doesn\u2019t Have the Same Weight Loss Effect as GLP-1 <\/span> <\/h2>\n<p id=\"mntl-sc-block_29-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> ENV-308 may help keep weight off after discontinuing GLP-1 treatment, but it won\u2019t likely have a comparable weight loss effect, says Lofton.\n<\/p>\n<div id=\"mntl-sc-block_30-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_31-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cThe fact that you\u2019re getting Lac-Phe with ENV-308 could mean that we have better maintenance for weight that\u2019s been lost than we do right now, when we discontinued GLP-1,\u201d Lofton said.\n<\/p>\n<div id=\"mntl-sc-block_32-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_33-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> She said that ENV-308 won\u2019t disrupt the GLP-1 industry and instead praised the idea of developing more than one medication for obesity. Various <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/7-fda-approved-drugs-for-weight-management-7568596\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">weight loss drugs<\/a> are being clinically tested, including <a class=\"recommendation-inline-link\" href=\"https:\/\/www.verywellhealth.com\/retatrutide-weight-loss-11913706\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"2\" rel=\"noopener noreferrer\">retatrutide<\/a>, which was recently found to help people lose an average of 28.3% of their body weight over a period of 80 weeks in a Phase 3 trial.<span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-7\" tabindex=\"0\">6<\/span><span class=\"mntl-inline-citation mntl-dynamic-tooltip--trigger\" data-id=\"#citation-9\" tabindex=\"0\">7<\/span>\n<\/p>\n<div id=\"mntl-sc-block_34-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_35-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cWe still have an obesity issue in America and around the world. So we\u2019re beginning to change the narrative around obesity as a weight loss goal, but a chronic condition that needs long-term disease management,\u201d Lofton said. \u201cWe may need multiple therapies for long-term maintenance. ENV-308 is really interesting because it potentially addresses that in a different way.\u201d\n<\/p>\n<div id=\"mntl-sc-block_36-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-env-308-wouldnt-replace-the-benefits-of-exercise\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_37-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> ENV-308 Wouldn\u2019t Replace the Benefits of Exercise <\/span> <\/h2>\n<p id=\"mntl-sc-block_38-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Despite ENV-308\u2019s potential to preserve lean mass and prevent weight regain, it would not replace the benefits of exercise, Varney said.\n<\/p>\n<div id=\"mntl-sc-block_39-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_40-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cExercise is necessary because it\u2019s good for your heart, lungs, circulation, sleep, and weight maintenance,\u201d she added. \u201cWhen these weight loss medications are studied, they are always studied in combination with a reduced-calorie diet and exercise. So the medications will work best when combined with that.\u201d\n<\/p>\n<div id=\"mntl-sc-block_41-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_42-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> ENV-308 is still in the early stages of clinical testing and could take at least three to five years until it can be reviewed and approved by the Food and Drug Administration, Varney said.\n<\/p>\n<\/div>\n<div id=\"post-article_1-0\" class=\"comp post-article mntl-block\">\n<div id=\"breadcrumbs--chips_1-0\" class=\"comp breadcrumbs--chips mntl-universal-breadcrumbs--chips mntl-block\">\n<div id=\"mntl-breadcrumbs__read-more_1-0\" class=\"comp mntl-breadcrumbs__read-more mntl-text-block text-title-100\">Read More:<\/div>\n<ul id=\"mntl-universal-breadcrumbs_1-0\" class=\"comp mntl-universal-breadcrumbs mntl-block breadcrumbs\" data-tracking-container=\"true\">\n<li id=\"mntl-breadcrumbs__item_1-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/prevention-and-treatment-4158390\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_5-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Prevention &amp; Treatment<\/span><\/a><\/li>\n<li id=\"mntl-breadcrumbs__item_2-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/prescription-and-otc-drugs-8640681\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_6-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Drugs<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n<div id=\"sources_1-0\" class=\"comp sources mntl-block\">\n<div id=\"mntl-article-sources_1-0\" class=\"comp mntl-article-sources mntl-expandable-block\" data-scroll-offset=\"70\">\n<div class=\"loc toggle-content\">\n<div id=\"mntl-article-sources__wrapper_1-0\" class=\"comp mntl-article-sources__wrapper mntl-block\" data-click-tracked=\"true\" tabindex=\"0\"><span id=\"mntl-article-sources__heading_1-0\" class=\"comp mntl-article-sources__heading mntl-text-block\">7 Sources<\/span><br \/>\n<svg class=\"icon show-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#show-icon\" href=\"#show-icon\"><\/use>\n<\/svg><br \/>\n<svg class=\"icon hide-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#hide-icon\" href=\"#hide-icon\"><\/use>\n<\/svg><\/div>\n<\/div>\n<div class=\"loc expandable-content\">\n<div id=\"source-guidelines_1-0\" class=\"comp source-guidelines mntl-text-block\">Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our <a href=\"\/verywell-editorial-process-4777042\">editorial process<\/a> to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.<\/div>\n<div id=\"mntl-article-sources__citation-sources_1-0\" class=\"comp mntl-article-sources__citation-sources mntl-citation-sources mntl-sources\" data-tracking-container=\"true\">\n<ol class=\"mntl-sources__content\">\n<li class=\"mntl-sources__source\" id=\"citation-1\">\n<p>Enveda. <a href=\"https:\/\/enveda.com\/news\/308-phase1\/\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Enveda reports positive phase 1 results for ENV-308, the first pill designed from the chemistry of exercise<\/a>.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-8\">\n<p>Li VL, He Y, Contrepois K, et al. <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-04828-5\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" rel=\"nofollow noopener\" target=\"_blank\">An exercise-inducible metabolite that suppresses feeding and obesity.<\/a>&nbsp;<em>Nature<\/em>. 2022;606(7915):785-790. doi:10.1038\/s41586-022-04828-5<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-2\">\n<p>Yao T, Wen GA, Wu Z, Shen N. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12558030\/\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Lac-Phe: a central metabolic regulator and biomarker<\/a>. <em>Med Rev (2021)<\/em>. 2025;5(5):429. doi:10.1515\/mr-2025-0030<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-5\">\n<p>Zhao S, Zhu Y, Schultz RD, et al. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6774814\/\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Partial leptin reduction as an insulin sensitization and weight loss strategy<\/a>. <em>Cell Metab<\/em>. 2019;30(4):706-719.e6. doi:10.1016\/j.cmet.2019.08.005<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-3\">\n<p>Alhazmi A, Roux CW le. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12992036\/\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Do no harm: managing nausea and vomiting in GLP-1 based obesity therapies<\/a>. <em>Frontiers in Endocrinology<\/em>. 2026;17:1788698. doi:10.3389\/fendo.2026.1788698<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-7\">\n<p>Bajaj HS, Welch M, Shah P, et al. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0140673626009670\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial.<\/a> <em>Lancet<\/em>. 2026;407(10546):2402-2413. doi:10.1016\/S0140-6736(26)00967-0<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-9\">\n<p>Eli Lilly and Company. <a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lillys-triple-agonist-retatrutide-delivered-powerful-weight-loss\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Lilly\u2019s triple agonist, retatrutide, delivered powerful weight loss in pivotal phase 3 obesity trial.<\/a><\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"trust-ribbon_1-0\" class=\"comp trust-ribbon trust-ribbon-expandable-block\">\n<div class=\"content-wrapper\">\n<div class=\"loc static-content\">\n<div id=\"trust-ribbon__editorial_1-0\" class=\"comp 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In Phase 1 trials, ENV-308 was well tolerated, showed rapid reductions in leptin levels, and prevented weight regain in animal&#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-70","post","type-post","status-publish","format-standard","hentry","category-chua-phan-loai"],"_links":{"self":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/70","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=70"}],"version-history":[{"count":0,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/70\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=70"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=70"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=70"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}