{"id":66,"date":"2026-11-06T09:06:25","date_gmt":"2026-11-06T09:06:25","guid":{"rendered":"https:\/\/healthcare.hibisports.com\/?p=66"},"modified":"2026-11-06T09:06:25","modified_gmt":"2026-11-06T09:06:25","slug":"mounjaro-gets-fda-approval-to-reduce-cardiovascular-risk-in-people-with-type-2-diabetes","status":"publish","type":"post","link":"https:\/\/healthcare.hibisports.com\/?p=66","title":{"rendered":"Mounjaro Gets FDA Approval to Reduce Cardiovascular Risk in People With Type 2 Diabetes"},"content":{"rendered":"<div id=\"health-sc-page_1-0\" class=\"comp health-sc-page mntl-sc-page mntl-block structured-content article-content expert-content right-rail__offset lock-journey\" data-sc-sticky-offset=\"60\" data-sc-ad-label-height=\"24\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"4\" data-sc-content-positions=\"[400, 1400, 1400, 1700, 2000, 2200, 2400, 2600, 2800]\" data-bind-scroll-on-start=\"true\">\n<div id=\"health-sc-block-callout--key-takeaway_1-0\" class=\"comp health-sc-block-callout--key-takeaway health-sc-block-callout-base mntl-sc-block-callout mntl-block theme-key-takeaway theme-key-takeaway\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<h3 id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key Takeaways<\/h3>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block expert-content\">\n<ul>\n<li>The FDA has approved Mounjaro to reduce the risk of heart attack or stroke in adults with type 2 diabetes who are at high risk for these events.<\/li>\n<li>In a study, Mounjaro reduced the risk of cardiovascular death, heart attack, or stroke by 8%, compared with Trulicity, an older GLP-1 treatment for type 2 diabetes.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The Food and Drug Administration (FDA) has approved Eli Lilly\u2019s blockbuster diabetes drug Mounjaro to reduce the risk of stroke or heart attack in adults with type 2 diabetes who are at high risk of cardiovascular events.\n<\/p>\n<div id=\"mntl-sc-block_3-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/fda-mounjaro-diabetes-treatment-5272486\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">Mounjaro is an injectable<\/a> for adults and children aged 10 years or older with type 2 diabetes. The version that\u2019s been approved for obesity is sold as Zepbound.\n<\/p>\n<div id=\"mntl-sc-block_5-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The new indication was based on the results of a head-to-head clinical trial that compared Mounjaro with Trulicity, Lilly\u2019s older GLP-1 treatment for type 2 diabetes.<span data-cite=\"2\" class=\"inline-citation-node\"><\/span> The study followed more than 13,000 participants across 30 countries for over four and a half years.\n<\/p>\n<div id=\"mntl-sc-block_7-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\">\n<div id=\"mm-ads-native_1-0\" class=\"comp mm-ads-native \" style=\"--native-ad-height: auto\" data-right-rail-index=\"1\">\n<div id=\"mm-ads-native__adunit_1-0\" class=\"comp mm-ads-native__adunit mm-ads-gpt-dynamic-adunit mm-ads-gpt-adunit scads-to-load gpt native js-immediate-ad js-immediate-ad-loaded\">\n<div id=\"native\" class=\"wrapper\" data-type=\"native\" data-pos=\"native\" data-priority=\"4\" data-sizes=\"[[1, 3],&quot;fluid&quot;]\" data-rtb=\"false\" data-wait-for-third-party=\"false\" data-targeting=\"{}\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Results found that Mounjaro had an 8% lower rate of cardiovascular death, heart attack, or stroke than Trulicity. There were some gastrointestinal-related side effects from Mounjaro, but they were generally mild to moderate in severity.\n<\/p>\n<div id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cHeart health deserves attention throughout the course of treatment, not just after a serious cardiovascular event,\u201d David A. D\u2019Alessio, MD, the study\u2019s co-author, said in<a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/fda-approves-lillys-mounjaro-tirzepatide-reduce-cardiovascular\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\"> a press release<\/a>. \u201cWhile a large portion of type 2 diabetes care is focused on glucose control, mitigating cardiovascular risk is essential and can be overlooked. This approval gives patients a medicine that reduces the risk of cardiovascular events and supports metabolic health at the same time.\u201d\n<\/p>\n<div id=\"mntl-sc-block_11-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<div id=\"health-sc-block-spotlight--none_1-0\" class=\"comp health-sc-block-spotlight--none health-sc-block-spotlight-base mntl-sc-block-spotlight mntl-block health-sc-block-spotlight theme-none theme-none\">\n<div id=\"mntl-sc-block-spotlight__articles_1-0\" class=\"comp mntl-sc-block-spotlight__articles mntl-document-spotlight mntl-document-card-list mntl-card-list mntl-block\" data-chunk=\"36\"><a id=\"mntl-card-list-items_1-0\" class=\"comp mntl-card-list-items mntl-document-card mntl-card card card--no-image\" data-doc-id=\"12033843\" data-tax-levels=\"\" href=\"https:\/\/www.verywellhealth.com\/supplements-to-take-with-glp-1s-12033843\" data-ordinal=\"1\" data-cta=\"Read Now \u25b8\"><\/p>\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<img data-src=\"https:\/\/www.verywellhealth.com\/thmb\/rKa6I5RWnQv7W9doDr4Rz5FYLMM=\/600x450\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg\" width=\"600\" height=\"450\" data-srcset=\"https:\/\/www.verywellhealth.com\/thmb\/-aweiGDhTWfYUjQYMJWBIHo3g7E=\/550x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 550w, https:\/\/www.verywellhealth.com\/thmb\/VU7j1O08OwZdbTH3ZTJ7sxvnG1w=\/587x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 587w, https:\/\/www.verywellhealth.com\/thmb\/vQ_pWLBJ5aJK5dRWtbd6754Wr-M=\/624x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 624w, https:\/\/www.verywellhealth.com\/thmb\/yzRWTsTa2rDGnDwp-uwOBmFsrnY=\/661x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 661w, https:\/\/www.verywellhealth.com\/thmb\/bMP5sE9ZhF2SEUF54bNxV-q7s_o=\/700x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 700w\" data-sizes=\"(max-width: 1248px) calc(60vw - 2rem), 554px\" alt=\"Person holding supplement capsules in hand\" class=\" card__img universal-image__image lazyloadwait\" data-expand=\"300\"><br \/>\n<noscript><br \/>\n<img\nsrc=\"https:\/\/www.verywellhealth.com\/thmb\/rKa6I5RWnQv7W9doDr4Rz5FYLMM=\/600x450\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg\"\nwidth=\"600\"\nheight=\"450\"\nclass=\"img--noscript card__img universal-image__image\"\nsrcset=\"https:\/\/www.verywellhealth.com\/thmb\/-aweiGDhTWfYUjQYMJWBIHo3g7E=\/550x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 550w, https:\/\/www.verywellhealth.com\/thmb\/VU7j1O08OwZdbTH3ZTJ7sxvnG1w=\/587x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 587w, https:\/\/www.verywellhealth.com\/thmb\/vQ_pWLBJ5aJK5dRWtbd6754Wr-M=\/624x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 624w, https:\/\/www.verywellhealth.com\/thmb\/yzRWTsTa2rDGnDwp-uwOBmFsrnY=\/661x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 661w, https:\/\/www.verywellhealth.com\/thmb\/bMP5sE9ZhF2SEUF54bNxV-q7s_o=\/700x0\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-1488399923-a0d406ea96b141e9bf0719d2ab66f19a.jpg 700w\"\nsizes=\"(max-width: 1248px) calc(60vw - 2rem), 554px\"\nalt=\"Person holding supplement capsules in hand\"\n\/><br \/>\n<\/noscript>\n<\/div>\n<\/div>\n<div class=\"card__content \" data-tag=\"Supplements\">\n<div class=\"card__header\"><\/div>\n<p><span class=\"card__title\"><span class=\"card__title-text \">6 Supplements That May Help While Taking GLP-1 Medications<\/span><\/span><\/p>\n<div class=\"card__byline mntl-card__byline \" data-byline=\"Medically reviewed by Kelly Wood, MD\"><\/div>\n<\/div>\n<p><\/a><\/div>\n<\/div>\n<div id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_14-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Eli Lilly\u2019s tirzepatide isn\u2019t the first GLP-1 drug to receive an FDA indication for reducing cardiovascular risks. Last year, the FDA approved Rybelsus, an oral GLP-1 medicine manufactured by Novo Nordisk, for reducing the risk of cardiovascular events in high-risk adults with type 2 diabetes.<span data-cite=\"3\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> In 2024, the FDA also approved Novo Nordisk\u2019s Wegovy, an <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/wegovy-semaglutide-for-weight-loss-8550138\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">injectable version of semaglutide<\/a> for weight loss, to reduce the risk of serious heart-related issues in adults with cardiovascular disease who have either obesity or overweight.<span data-cite=\"4\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<\/div>\n<div id=\"post-article_1-0\" class=\"comp post-article mntl-block\">\n<div id=\"breadcrumbs--chips_1-0\" class=\"comp breadcrumbs--chips mntl-universal-breadcrumbs--chips mntl-block\">\n<div id=\"mntl-breadcrumbs__read-more_1-0\" class=\"comp mntl-breadcrumbs__read-more mntl-text-block text-title-100\">Read More:<\/div>\n<ul id=\"mntl-universal-breadcrumbs_1-0\" class=\"comp mntl-universal-breadcrumbs mntl-block breadcrumbs\" data-tracking-container=\"true\">\n<li id=\"mntl-breadcrumbs__item_1-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/prevention-and-treatment-4158390\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_5-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Prevention &amp; Treatment<\/span><\/a><\/li>\n<li id=\"mntl-breadcrumbs__item_2-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/prescription-and-otc-drugs-8640681\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_6-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Drugs<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n<div id=\"sources_1-0\" class=\"comp sources mntl-block\">\n<div id=\"mntl-article-sources_1-0\" class=\"comp mntl-article-sources mntl-expandable-block\" data-scroll-offset=\"70\">\n<div class=\"loc toggle-content\">\n<div id=\"mntl-article-sources__wrapper_1-0\" class=\"comp mntl-article-sources__wrapper mntl-block\" data-click-tracked=\"true\" tabindex=\"0\"><span id=\"mntl-article-sources__heading_1-0\" class=\"comp mntl-article-sources__heading mntl-text-block\">3 Sources<\/span><br \/>\n<svg class=\"icon show-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#show-icon\" href=\"#show-icon\"><\/use>\n<\/svg><br \/>\n<svg class=\"icon hide-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#hide-icon\" href=\"#hide-icon\"><\/use>\n<\/svg><\/div>\n<\/div>\n<div class=\"loc expandable-content\">\n<div id=\"source-guidelines_1-0\" class=\"comp source-guidelines mntl-text-block\">Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our <a href=\"\/verywell-editorial-process-4777042\">editorial process<\/a> to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.<\/div>\n<div id=\"mntl-article-sources__citation-sources_1-0\" class=\"comp mntl-article-sources__citation-sources mntl-citation-sources mntl-sources\" data-tracking-container=\"true\">\n<ol class=\"mntl-sources__content\">\n<li class=\"mntl-sources__source\" id=\"citation-2\">\n<p>Nicholls SJ, Pavo I, Bhatt DL, et al. <a href=\"https:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMoa2505928\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Cardiovascular outcomes with tirzepatide versus dulaglutide in type 2 diabetes<\/a>. <em>N Engl J Med<\/em>. 2025;393(24):2409-2420. doi:10.1056\/NEJMoa2505928<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-3\">\n<p>Novo Nordisk. <a href=\"https:\/\/www.novonordisk-us.com\/media\/news-archive\/news-details.html?id=916435\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">FDA approves Novo Nordisk\u2019s oral semaglutide for cardiovascular (CV) risk reduction in adults with type 2 diabetes who are at high risk, including those who have not had a prior CV event<\/a>.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-4\">\n<p>Food and Drug Administration. <a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-treatment-reduce-risk-serious-heart-problems-specifically-adults-obesity-or\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">FDA approves first treatment to reduce risk of serious heart problems specifically in adults with obesity or overweight.<\/a><\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"trust-ribbon_1-0\" class=\"comp trust-ribbon trust-ribbon-expandable-block\">\n<div class=\"content-wrapper\">\n<div class=\"loc static-content\">\n<div id=\"trust-ribbon__editorial_1-0\" class=\"comp trust-ribbon__editorial trust-ribbon-item mntl-block\"><svg class=\"icon trust-ribbon-item__icon-editorial \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#trust-ribbon-item__icon-editorial\" href=\"#trust-ribbon-item__icon-editorial\"><\/use>\n<\/svg><br \/>\n<a href=\"\/verywell-editorial-process-4777042\" rel=\"nocaes\" class=\"trust-ribbon-item__text mntl-text-link \" id=\"trust-ribbon-item__text_1-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">See Our Editorial Process<\/span><\/a><\/div>\n<div id=\"trust-ribbon__review_1-0\" class=\"comp trust-ribbon__review trust-ribbon-item mntl-block\"><svg class=\"icon reviewer-icon 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In a study, Mounjaro reduced the risk of cardiovascular death,&#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-66","post","type-post","status-publish","format-standard","hentry","category-chua-phan-loai"],"_links":{"self":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/66","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=66"}],"version-history":[{"count":0,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/66\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=66"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=66"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=66"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}