{"id":65,"date":"2026-11-06T09:06:25","date_gmt":"2026-11-06T09:06:25","guid":{"rendered":"https:\/\/healthcare.hibisports.com\/?p=65"},"modified":"2026-11-06T09:06:25","modified_gmt":"2026-11-06T09:06:25","slug":"why-some-people-are-taking-an-erectile-dysfunction-drug-to-live-longer","status":"publish","type":"post","link":"https:\/\/healthcare.hibisports.com\/?p=65","title":{"rendered":"Why Some People Are Taking an Erectile Dysfunction Drug to Live Longer"},"content":{"rendered":"<div id=\"health-sc-page_1-0\" class=\"comp health-sc-page mntl-sc-page mntl-block structured-content article-content expert-content right-rail__offset lock-journey\" data-sc-sticky-offset=\"60\" data-sc-ad-label-height=\"24\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"4\" data-sc-content-positions=\"[400, 1400, 1400, 1700, 2000, 2200, 2400, 2600, 2800]\" data-bind-scroll-on-start=\"true\">\n<div id=\"health-sc-block-callout--key-takeaway_1-0\" class=\"comp health-sc-block-callout--key-takeaway health-sc-block-callout-base mntl-sc-block-callout mntl-block theme-key-takeaway theme-key-takeaway\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<h3 id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key Takeaways<\/h3>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block expert-content\">\n<ul>\n<li>Tadalafil is the active ingredient in Cialis, a drug used to treat erectile dysfunction.<\/li>\n<li>Some studies have linked tadalafil use to heart health benefits and a lower risk of early death.<\/li>\n<li>Now, some wellness enthusiasts are taking the drug in hopes that it will extend their lifespan. <\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Some men are finding a new purpose for the erectile dysfunction drug tadalafil (sold as Cialis) beyond extending their erections: They believe a daily dose of this pill could help them live longer.\n<\/p>\n<div id=\"mntl-sc-block_3-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> This daily, long-acting ED pill can improve blood flow, and studies suggest it may also boost cardiovascular and cognitive health.<span data-cite=\"1\" class=\"inline-citation-node\"><\/span><span data-cite=\"2\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_5-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-why-is-tadalafil-linked-to-longevity\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> Why Is Tadalafil Linked to Longevity? <\/span> <\/h2>\n<p id=\"mntl-sc-block_7-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/this-is-how-cialis-works-7967620\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">Phosphodiesterase 5 (PDE5) inhibitors<\/a>, a class of drugs that includes <a class=\"recommendation-inline-link\" href=\"https:\/\/www.verywellhealth.com\/cialis-vs-viagra-effectiveness-dosage-and-safety-7091128\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"2\" rel=\"noopener noreferrer\">tadalafil and Viagra (sildenafil)<\/a>, were originally studied for treating high blood pressure and cardiovascular disease.<span data-cite=\"3\" class=\"inline-citation-node\"><\/span> Researchers later discovered that PDE5 inhibitors offer benefits for ED, so manufacturers focused on&nbsp;this as the primary indication instead.\n<\/p>\n<div id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\">\n<div id=\"mm-ads-native_1-0\" class=\"comp mm-ads-native \" style=\"--native-ad-height: auto\" data-right-rail-index=\"1\">\n<div id=\"mm-ads-native__adunit_1-0\" class=\"comp mm-ads-native__adunit mm-ads-gpt-dynamic-adunit mm-ads-gpt-adunit scads-to-load gpt native js-immediate-ad js-immediate-ad-loaded\">\n<div id=\"native\" class=\"wrapper\" data-type=\"native\" data-pos=\"native\" data-priority=\"4\" data-sizes=\"[[1, 3],&quot;fluid&quot;]\" data-rtb=\"false\" data-wait-for-third-party=\"false\" data-targeting=\"{}\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> But researchers have continued to investigate whether PDE5 inhibitors could have other health benefits.\n<\/p>\n<div id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_11-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> A 2025 observational study linked the use of tadalafil, the active ingredient in Cialis,<strong> <\/strong>to a 34% lower risk of death, a 27% lower risk of heart attack, a 34% lower risk of stroke, and a 32% lower risk of dementia.<span data-cite=\"2\" class=\"inline-citation-node\"><\/span> Longevity influencer Bryan Johnson cited these findings in a social media post explaining why he takes 5 milligrams (mg) of tadalafil daily.\n<\/p>\n<div id=\"mntl-sc-block_12-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cOther studies found somewhere around a 44% to 55% lower risk of death or heart-related death. Those numbers sound huge, and I get why Bryan Johnson and others latched onto them,\u201d <a class=\"\" href=\"https:\/\/www.researchgate.net\/profile\/Martin-Gross-16\" data-type=\"\" data-component=\"link\" data-source=\"inlineLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\" target=\"_blank\">Martin Gross, MD<\/a>, a urologist specializing in sexual medicine and reproductive health at Yale New Haven Health and associate professor of urology at Yale School of Medicine, who was not involved in the study, told Verywell<em> <\/em>in an email.<span data-cite=\"5\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_14-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> However, these studies were observational, meaning researchers looked for patterns in existing health data. They were not clinical trials where researchers randomly assigned people to take tadalafil or a placebo, so the findings cannot prove that the drug can reduce the risk of heart attacks, dementia, or early death, Gross said.\n<\/p>\n<div id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-cialis-tadalafil-vs-viagra-sildenafil\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_17-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> Cialis (tadalafil) vs. Viagra (sildenafil) <\/span> <\/h2>\n<p id=\"mntl-sc-block_18-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The 2025 study linked both tadalafil and sildenafil to longevity benefits, but the association was stronger for tadalafil.<span data-cite=\"2\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_19-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_20-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> One possible explanation is how long the drugs stay in the body.<strong> <\/strong>Tadalafil can remain active for up to 36 hours, compared with about four to five hours for sildenafil.\n<\/p>\n<div id=\"mntl-sc-block_21-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_22-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cBecause it helps keep blood vessels relaxed for a longer period of time, tadalafil may improve blood flow throughout the body, including the heart, brain, and the body\u2019s smallest blood vessels. It may also reduce the tendency of platelets to form clots and lessen cell damage caused by harmful oxygen molecules, known as oxidative stress. Together, these effects could potentially help protect the heart and other organs,\u201d said <a class=\"\" href=\"https:\/\/www.utmb.edu\/emergency-med\/director\" data-type=\"\" data-component=\"link\" data-source=\"inlineLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\" target=\"_blank\">Dietrich Jehle, MD<\/a>, first author of the study and program director, professor, and chair of the Department of Emergency Medicine at the University of Texas Medical Branch in Galveston, Texas.\n<\/p>\n<div id=\"mntl-sc-block_23-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<div id=\"health-sc-block-spotlight--mid-circ_1-0\" class=\"comp health-sc-block-spotlight--mid-circ mntl-sc-block-spotlight--mid-circ mntl-block theme-mid-circ theme-mid-circ\" data-use-proximity=\"true\">\n<h2 id=\"midcirc__heading_1-0\" class=\"comp midcirc__heading mntl-text-block\">Related Stories<\/h2>\n<div id=\"midcirc__card-list_1-0\" class=\"comp midcirc__card-list mntl-block\"><a href=\"https:\/\/www.verywellhealth.com\/glp-1-drugs-blood-pressure-11979086\" rel=\"nocaes\" data-card-index=\"0\" data-click-tracked=\"false\" id=\"midcirc-card_1-0\" class=\"midcirc-card mntl-midcirc-card mntl-text-link \" data-tracking-container=\"true\"><\/p>\n<div id=\"midcirc-card__title_1-0\" class=\"comp midcirc-card__title mntl-text-block\">New Research Shows GLP-1 Drugs May Help Reduce Blood Pressure<\/div>\n<div id=\"midcirc-card__image-wrapper_1-0\" class=\"comp midcirc-card__image-wrapper mntl-block\">\n<div class=\"midcirc-card__image mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\" style=\"padding-bottom:66.6%;\">\n<img data-src=\"https:\/\/www.verywellhealth.com\/thmb\/JA6dov_zpWD161B-RfXeeqgylIY=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-2277072224-253694d5d5264cc6b2ba7d55e3d92845.jpg\" width=\"300\" height=\"200\" alt=\"Table with medicine blister packs water glass and GLP-1\" class=\" universal-image__image lazyloadwait\"><br \/>\n<noscript><br \/>\n<img\nsrc=\"https:\/\/www.verywellhealth.com\/thmb\/JA6dov_zpWD161B-RfXeeqgylIY=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-2277072224-253694d5d5264cc6b2ba7d55e3d92845.jpg\"\nwidth=\"300\"\nheight=\"200\"\nclass=\"img--noscript universal-image__image\"\nalt=\"Table with medicine blister packs water glass and GLP-1\"\n\/><br \/>\n<\/noscript>\n<\/div>\n<\/div>\n<\/div>\n<p><\/a><br \/>\n<a href=\"https:\/\/www.verywellhealth.com\/benefits-of-metformin-beyond-blood-sugar-12177130\" rel=\"nocaes\" data-card-index=\"1\" data-click-tracked=\"false\" id=\"midcirc-card_2-0\" class=\"midcirc-card mntl-midcirc-card mntl-text-link \" data-tracking-container=\"true\"><\/p>\n<div id=\"midcirc-card__title_2-0\" class=\"comp midcirc-card__title mntl-text-block\">3 Health Benefits of Metformin Beyond Blood Sugar, According to a PharmD<\/div>\n<div id=\"midcirc-card__image-wrapper_2-0\" class=\"comp midcirc-card__image-wrapper mntl-block\">\n<div class=\"midcirc-card__image mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\" style=\"padding-bottom:66.6%;\">\n<img data-src=\"https:\/\/www.verywellhealth.com\/thmb\/HGL9w2QjTTCru7ZuTBJ1jzPmDo8=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-2219773997-1da4b366f2b845bc85578e21ce65f56b.jpg\" width=\"300\" height=\"200\" alt=\"Person sitting on couch holding medication pills and glass of water\" class=\" universal-image__image lazyloadwait\"><br \/>\n<noscript><br \/>\n<img\nsrc=\"https:\/\/www.verywellhealth.com\/thmb\/HGL9w2QjTTCru7ZuTBJ1jzPmDo8=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/VWH-GettyImages-2219773997-1da4b366f2b845bc85578e21ce65f56b.jpg\"\nwidth=\"300\"\nheight=\"200\"\nclass=\"img--noscript universal-image__image\"\nalt=\"Person sitting on couch holding medication pills and glass of water\"\n\/><br \/>\n<\/noscript>\n<\/div>\n<\/div>\n<\/div>\n<p><\/a><\/div>\n<\/div>\n<div id=\"mntl-sc-block_25-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-men-who-take-cialis-are-often-already-healthier\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_26-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> Men Who Take Cialis Are Often Already Healthier <\/span> <\/h2>\n<p id=\"mntl-sc-block_27-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The observational studies also have another important limitation: healthy-user bias. Someone who takes tadalafil is different from people who don\u2019t.\n<\/p>\n<div id=\"mntl-sc-block_28-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_29-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cHe\u2019s sexually active, he has a partner, he\u2019s engaged with the healthcare system, he showed up for a visit and asked for something. Those are all independently associated with living longer,\u201d <a class=\"\" href=\"https:\/\/www.feinberg.northwestern.edu\/faculty-profiles\/az\/profile.html?xid=35175\" data-type=\"\" data-component=\"link\" data-source=\"inlineLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\" target=\"_blank\">Nelson E. Bennett Jr., MD<\/a>, a professor of urology at Northwestern University Feinberg School of Medicine, in Chicago, told Verywell in an email.\n<\/p>\n<div id=\"mntl-sc-block_30-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_31-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The bigger longevity benefit may have less to do with the ED drug itself and more to do with being proactive about doctor\u2019s visits.&nbsp;ED is often an early sign of cardiovascular disease, so identifying and treating this can keep someone healthier for longer.<span data-cite=\"4\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_32-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_33-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cThe penis is a vascular organ with small arteries, so it fails early. A man in his 40s with new ED and no obvious cause deserves a cardiometabolic workup, not just a prescription. That\u2019s the real longevity intervention hiding inside this conversation,\u201d Bennett said.\n<\/p>\n<div id=\"mntl-sc-block_34-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-potential-side-effects-of-tadalafil\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_35-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> Potential Side Effects of Tadalafil <\/span> <\/h2>\n<p id=\"mntl-sc-block_36-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Despite the lack of randomized controlled trials, online marketplaces and telehealth platforms provide tadalafil prescriptions to both men and women for longevity.\n<\/p>\n<div id=\"mntl-sc-block_37-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_38-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cNone of this research includes women, even though some of these clinics are marketing tadalafil to them, too, for reasons it isn\u2019t approved for. We simply don\u2019t have safety data there,\u201d Gross said.&nbsp;\n<\/p>\n<div id=\"mntl-sc-block_39-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_40-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> It is risky to combine certain medications, especially nitrates, with tadalafil because your <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/low-blood-pressure-symptoms-11779742\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">blood pressure may drop too low<\/a>.<span data-cite=\"1\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_41-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_42-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cIf you\u2019re curious, talk to your own doctor, someone who knows your actual health risks and your medication list, not an online form built to sell you a subscription. And if you\u2019re already a good candidate for tadalafil for its approved use, the boring stuff\u2014exercise, sleep, not smoking, keeping your blood pressure and cholesterol in check\u2014is still doing more of the real work than the pill is,\u201d Gross said.\n<\/p>\n<\/div>\n<div id=\"post-article_1-0\" class=\"comp post-article mntl-block\">\n<div id=\"breadcrumbs--chips_1-0\" class=\"comp breadcrumbs--chips mntl-universal-breadcrumbs--chips mntl-block\">\n<div id=\"mntl-breadcrumbs__read-more_1-0\" class=\"comp mntl-breadcrumbs__read-more mntl-text-block text-title-100\">Read More:<\/div>\n<ul id=\"mntl-universal-breadcrumbs_1-0\" class=\"comp mntl-universal-breadcrumbs mntl-block breadcrumbs\" data-tracking-container=\"true\">\n<li id=\"mntl-breadcrumbs__item_1-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/prevention-and-treatment-4158390\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_5-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Prevention &amp; Treatment<\/span><\/a><\/li>\n<li id=\"mntl-breadcrumbs__item_2-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/prescription-and-otc-drugs-8640681\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_6-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Drugs<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n<div id=\"sources_1-0\" class=\"comp sources mntl-block\">\n<div id=\"mntl-article-sources_1-0\" class=\"comp mntl-article-sources mntl-expandable-block\" data-scroll-offset=\"70\">\n<div class=\"loc toggle-content\">\n<div id=\"mntl-article-sources__wrapper_1-0\" class=\"comp mntl-article-sources__wrapper mntl-block\" data-click-tracked=\"true\" tabindex=\"0\"><span id=\"mntl-article-sources__heading_1-0\" class=\"comp mntl-article-sources__heading mntl-text-block\">5 Sources<\/span><br \/>\n<svg class=\"icon show-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#show-icon\" href=\"#show-icon\"><\/use>\n<\/svg><br \/>\n<svg class=\"icon hide-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#hide-icon\" href=\"#hide-icon\"><\/use>\n<\/svg><\/div>\n<\/div>\n<div class=\"loc expandable-content\">\n<div id=\"source-guidelines_1-0\" class=\"comp source-guidelines mntl-text-block\">Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our <a href=\"\/verywell-editorial-process-4777042\">editorial process<\/a> to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.<\/div>\n<div id=\"mntl-article-sources__citation-sources_1-0\" class=\"comp mntl-article-sources__citation-sources mntl-citation-sources mntl-sources\" data-tracking-container=\"true\">\n<ol class=\"mntl-sources__content\">\n<li class=\"mntl-sources__source\" id=\"citation-1\">\n<p>MedlinePlus. <a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a604008.html\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Tadalafil<\/a>.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-2\">\n<p>Jehle DVK, Sunesra R, Uddin H, et al. <a href=\"https:\/\/doi.org\/10.1016\/j.amjmed.2024.10.039\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Benefits of tadalafil and sildenafil on mortality, cardiovascular disease, and dementia<\/a>. <em>Am J Med.<\/em> 2025;138(3):441-448.e3. doi:10.1016\/j.amjmed.2024.10.039<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-3\">\n<p>Shawish MI, Ben-Eltriki M, Wright JM. <a href=\"http:\/\/doi.org\/10.1002\/14651858.CD013507\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Effect of phosphodiesterase 5 inhibitors on blood pressure.<\/a> Cochrane Database of Systematic Reviews. 2019. doi.org\/10.1002\/14651858.CD013507<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-5\">\n<p>Kloner RA, Stanek E, Desai K, et al. <a href=\"https:\/\/doi.org\/10.1002\/clc.24234Digital Object Identifier %28DOI%29\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">The association of tadalafil exposure with lower rates of major adverse cardiovascular events and mortality in a general population of men with erectile dysfunction<\/a>. <em>Clin Cardiol<\/em>. 2024;47(2):e24234. doi:10.1002\/clc.24234<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-4\">\n<p>Yannas D, Frizza F, Vignozzi L, Corona G, Maggi M, Rastrelli G. <a href=\"http:\/\/doi.org\/10.3390\/jcm10102221\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Erectile dysfunction is a hallmark of cardiovascular disease: unavoidable matter of fact or opportunity to improve men\u2019s health<\/a>? <em>J Clin Med<\/em>. 2021;10(10):2221. doi:10.3390\/jcm10102221<\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"author-bio_1-0\" class=\"comp author-bio\">\n<div class=\"loc author-bio__image\">\n<img data-src=\"https:\/\/www.verywellhealth.com\/thmb\/hEZrL73FFGkN98J34JAaeHp5A2Q=\/144x144\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/StephanieBrownnewheadshot-e5ca9ba2a404491384e9300a7871f190.jpg\" width=\"144\" height=\"144\" alt=\"Stephanie Brown\" class=\" author-bio__image mntl-image universal-image__image lazyloadwait\" data-expand=\"300\"><br \/>\n<noscript><br \/>\n<img\nsrc=\"https:\/\/www.verywellhealth.com\/thmb\/hEZrL73FFGkN98J34JAaeHp5A2Q=\/144x144\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/StephanieBrownnewheadshot-e5ca9ba2a404491384e9300a7871f190.jpg\"\nwidth=\"144\"\nheight=\"144\"\nclass=\"img--noscript author-bio__image mntl-image universal-image__image\"\nalt=\"Stephanie Brown\"\n\/><br \/>\n<\/noscript>\n<\/div>\n<p class=\"author-bio__bio-text\">\n<span class=\"author-bio__bio-title\">By <a href=\"https:\/\/www.verywellhealth.com\/stephanie-brown-5197949\">Stephanie Brown<\/a><\/span><br \/>\n<br \/>\nBrown is a nutrition writer who received her Didactic Program in Dietetics certification from the University of Tennessee at Knoxville. Previously, she worked as a nutrition educator and culinary instructor in New York City.\n<\/p>\n<\/div>\n<div id=\"trust-ribbon_1-0\" class=\"comp trust-ribbon trust-ribbon-expandable-block\">\n<div class=\"content-wrapper\">\n<div class=\"loc static-content\">\n<div id=\"trust-ribbon__editorial_1-0\" class=\"comp trust-ribbon__editorial trust-ribbon-item mntl-block\"><svg class=\"icon trust-ribbon-item__icon-editorial \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#trust-ribbon-item__icon-editorial\" href=\"#trust-ribbon-item__icon-editorial\"><\/use>\n<\/svg><br \/>\n<a href=\"\/verywell-editorial-process-4777042\" rel=\"nocaes\" class=\"trust-ribbon-item__text mntl-text-link \" id=\"trust-ribbon-item__text_1-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">See Our Editorial Process<\/span><\/a><\/div>\n<div id=\"trust-ribbon__review_1-0\" class=\"comp trust-ribbon__review trust-ribbon-item mntl-block\"><svg class=\"icon reviewer-icon trust-ribbon-item__icon-review\">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#reviewer-icon\" href=\"#reviewer-icon\"><\/use>\n<\/svg><br \/>\n<a href=\"\/meet-our-medical-expert-board-11762003\" rel=\"nocaes\" class=\"trust-ribbon-item__text mntl-text-link \" id=\"trust-ribbon-item__text_2-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Meet Our Medical Expert Board<\/span><\/a><\/div>\n<\/div>\n<div class=\"loc toggle-content\">\n<div id=\"trust-ribbon__feedback_1-0\" class=\"comp trust-ribbon__feedback trust-ribbon-item mntl-block\"><svg class=\"icon trust-ribbon-item__icon-feedback \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#trust-ribbon-item__icon-feedback\" href=\"#trust-ribbon-item__icon-feedback\"><\/use>\n<\/svg><br \/>\n<button id=\"trust-ribbon-item__text_3-0\" class=\"comp trust-ribbon-item__text mntl-text-block\">Share Feedback<\/button><\/div>\n<\/div><\/div>\n<div class=\"loc expandable-content\">\n<div id=\"trust-ribbon__feedback-block_1-0\" class=\"comp trust-ribbon__feedback-block article-feedback mntl-article-feedback\">\n<div class=\"article-feedback__rating-section js-rating-section is-hidden\">\n<div class=\"article-feedback__heading\">Was this page helpful?<\/div>\n<\/div>\n<div class=\"article-feedback__success-section js-success-section is-hidden\">\n<div class=\"article-feedback__heading\">Thanks for your feedback!<\/div>\n<\/div>\n<div class=\"article-feedback__feedback-section js-feedback-section\">\n<div class=\"article-feedback__heading\">What is your feedback?<\/div>\n<p><button id=\"helpful-button_1-0\" class=\"comp helpful-button mntl-button article-feedback__feedback-button\"> Helpful<br \/>\n<\/button><br \/>\n<button id=\"report-error-button_1-0\" class=\"comp report-error-button mntl-button article-feedback__feedback-button\"> Report an Error<br \/>\n<\/button><br \/>\n<button id=\"other-button_1-0\" class=\"comp other-button mntl-button article-feedback__feedback-button\"> Other<br \/>\n<\/button><br \/>\n<svg class=\"icon icon-x close-button\">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#icon-x\" href=\"#icon-x\"><\/use>\n<\/svg> <\/p>\n<form action=\"\/ugc-feedback\" method=\"post\" class=\"article-feedback__feedback-form js-feedback-form\">\n<textarea class=\"article-feedback__feedback-text js-feedback-text\" placeholder=\"Tell us more...\" required=\"required\" maxlength=\"1500\"><\/textarea><br \/>\n<button id=\"article-feedback__submit-button_1-0\" class=\"comp article-feedback__submit-button mntl-button\"> Submit<br \/>\n<\/button> <input type=\"hidden\" name=\"doc-id\" value=\"12063357\" class=\"js-doc-id\"><br \/>\n<\/form>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Key Takeaways Tadalafil is the active ingredient in Cialis, a drug used to treat erectile dysfunction. Some studies have linked tadalafil use to heart health benefits and a lower risk of early death. Now, some wellness enthusiasts are taking the&#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-65","post","type-post","status-publish","format-standard","hentry","category-chua-phan-loai"],"_links":{"self":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/65","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=65"}],"version-history":[{"count":0,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/65\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=65"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=65"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=65"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}