{"id":63,"date":"2026-11-06T09:06:25","date_gmt":"2026-11-06T09:06:25","guid":{"rendered":"https:\/\/healthcare.hibisports.com\/?p=63"},"modified":"2026-11-06T09:06:25","modified_gmt":"2026-11-06T09:06:25","slug":"does-the-new-mrna-flu-shot-work-better-than-a-traditional-flu-shot-what-the-science-says","status":"publish","type":"post","link":"https:\/\/healthcare.hibisports.com\/?p=63","title":{"rendered":"Does the New mRNA Flu Shot Work Better Than a Traditional Flu Shot? What the Science Says"},"content":{"rendered":"<div id=\"health-sc-page_1-0\" class=\"comp health-sc-page mntl-sc-page mntl-block structured-content article-content expert-content right-rail__offset lock-journey\" data-sc-sticky-offset=\"60\" data-sc-ad-label-height=\"24\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"4\" data-sc-content-positions=\"[400, 1400, 1400, 1700, 2000, 2200, 2400, 2600, 2800]\" data-bind-scroll-on-start=\"true\">\n<div id=\"health-sc-block-callout--key-takeaway_1-0\" class=\"comp health-sc-block-callout--key-takeaway health-sc-block-callout-base mntl-sc-block-callout mntl-block theme-key-takeaway theme-key-takeaway\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<h3 id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key takeaways<\/h3>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block expert-content\">\n<ul>\n<li>The FDA approved mFLUSIVA, the first mRNA flu vaccine, for adults 50 and older.<\/li>\n<li>Clinical trials showed that mFLUSIVA was approximately 27% more effective than the standard flu shot.<\/li>\n<li>The mRNA technology allows scientists to match current flu strains more quickly than traditional protein-based flu shots.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> A new kind of flu shot will soon be available in the United States.\n<\/p>\n<div id=\"mntl-sc-block_3-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The Food and Drug Administration (FDA) has recently approved Moderna\u2019s mFLUSIVA, the first mRNA-based flu vaccine, for adults aged 50 and above. This type of vaccine, also used to protect against COVID-19, provides cells with instructions to produce an antigen that trains the immune system to respond to the virus.<span data-cite=\"1\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_5-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cEvery year, we chase changes in the flu virus to create new vaccines. Now the mRNA vaccine is more nimble. It\u2019s easier to produce, and the turnaround time from intent to final product is really short,\u201d <a href=\"https:\/\/www.yalemedicine.org\/specialists\/onyema-ogbuagu\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Onyema Ogbuagu, MD<\/a>, an infectious diseases specialist and professor of medicine and pharmacology at Yale School of Medicine, told <em>Verywell.<\/em>\n<\/p>\n<div id=\"mntl-sc-block_7-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\">\n<div id=\"mm-ads-native_1-0\" class=\"comp mm-ads-native \" style=\"--native-ad-height: auto\" data-right-rail-index=\"1\">\n<div id=\"mm-ads-native__adunit_1-0\" class=\"comp mm-ads-native__adunit mm-ads-gpt-dynamic-adunit mm-ads-gpt-adunit scads-to-load gpt native js-immediate-ad js-immediate-ad-loaded\">\n<div id=\"native\" class=\"wrapper\" data-type=\"native\" data-pos=\"native\" data-priority=\"4\" data-sizes=\"[[1, 3],&quot;fluid&quot;]\" data-rtb=\"false\" data-wait-for-third-party=\"false\" data-targeting=\"{}\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cIt is superior to prevailing vaccines and particularly better for populations that are quite disproportionately impacted by the flu,\u201d he added.\n<\/p>\n<div id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-how-effective-is-modernas-mrna-flu-shot\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> How Effective Is Moderna\u2019s mRNA Flu Shot? <\/span> <\/h2>\n<p id=\"mntl-sc-block_11-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> A clinical trial found that mFLUSIVA was 26.6% more effective than the standard flu shot for adults 50 and older. Only 2% of participants who received mFLUSIVA developed the flu, compared with 2.8% who received the standard-dose vaccine.<span data-cite=\"7\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_12-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Another clinical trial compared mFLUSIVA with Fluzone High-Dose, a vaccine designed for older adults. Researchers found that mFLUSIVA helped the body build a stronger immune response in adults 65 and over.<span data-cite=\"8\" class=\"inline-citation-node\"><\/span><span data-cite=\"11\" class=\"inline-citation-node\"><\/span> However, research is ongoing to confirm whether that translates into better protection against the flu in this age group.\n<\/p>\n<div id=\"mntl-sc-block_14-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cThe recent<em> <\/em>study only compared and was more effective than the standard dose vaccine in adults over 50,\u201d <a href=\"https:\/\/providers.dartmouth-health.org\/1207\/rebecca-wang\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" rel=\"nofollow noopener\" target=\"_blank\">Rebecca Wang, MD<\/a>, an infectious disease physician at Dartmouth Hitchcock Medical Center, said. \u201cIt\u2019s hard to say for sure that someone age 65 should get this new mRNA instead of the enhanced vaccine that\u2019s already out there.\u201d\n<\/p>\n<div id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<div id=\"health-sc-block-spotlight--mid-circ_1-0\" class=\"comp health-sc-block-spotlight--mid-circ mntl-sc-block-spotlight--mid-circ mntl-block theme-mid-circ theme-mid-circ\" data-use-proximity=\"true\">\n<h2 id=\"midcirc__heading_1-0\" class=\"comp midcirc__heading mntl-text-block\">Related Stories<\/h2>\n<div id=\"midcirc__card-list_1-0\" class=\"comp midcirc__card-list mntl-block\"><a href=\"https:\/\/www.verywellhealth.com\/integrated\/flu-shot-side-effects-by-age-what-is-normal-and-what-is-not\" rel=\"nocaes\" data-card-index=\"0\" data-click-tracked=\"false\" id=\"midcirc-card_1-0\" class=\"midcirc-card mntl-midcirc-card mntl-text-link is-sponsored\" data-tracking-container=\"true\"><\/p>\n<div id=\"midcirc-card__title_1-0\" class=\"comp midcirc-card__title mntl-text-block\">Flu Shot Side Effects By Age: What\u2019s Normal and What\u2019s Not<\/div>\n<div id=\"midcirc-card__image-wrapper_1-0\" class=\"comp midcirc-card__image-wrapper mntl-block\">\n<div class=\"midcirc-card__image mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\" style=\"padding-bottom:66.6%;\">\n<img data-src=\"https:\/\/www.verywellhealth.com\/thmb\/YOXfnWbHVnkqHKUpir_8nGd-uWs=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/GettyImages-1448026218_4x3-7128d1fb678243bc89c05399bf4c212e.jpg\" width=\"300\" height=\"200\" alt=\"Person lying on a couch with a hand on their forehead appearing to be resting\" class=\" universal-image__image lazyloadwait\"><br \/>\n<noscript><br \/>\n<img\nsrc=\"https:\/\/www.verywellhealth.com\/thmb\/YOXfnWbHVnkqHKUpir_8nGd-uWs=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/GettyImages-1448026218_4x3-7128d1fb678243bc89c05399bf4c212e.jpg\"\nwidth=\"300\"\nheight=\"200\"\nclass=\"img--noscript universal-image__image\"\nalt=\"Person lying on a couch with a hand on their forehead appearing to be resting\"\n\/><br \/>\n<\/noscript>\n<\/div>\n<\/div>\n<\/div>\n<p><\/a><br \/>\n<a href=\"https:\/\/www.verywellhealth.com\/integrated\/who-is-eligible-for-a-senior-dose-flu-shot-this-year\" rel=\"nocaes\" data-card-index=\"1\" data-click-tracked=\"false\" id=\"midcirc-card_2-0\" class=\"midcirc-card mntl-midcirc-card mntl-text-link is-sponsored\" data-tracking-container=\"true\"><\/p>\n<div id=\"midcirc-card__title_2-0\" class=\"comp midcirc-card__title mntl-text-block\">Adults 65 and Older May Be Eligible for a Senior Dose Flu Shot This Year<\/div>\n<div id=\"midcirc-card__image-wrapper_2-0\" class=\"comp midcirc-card__image-wrapper mntl-block\">\n<div class=\"midcirc-card__image mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\" style=\"padding-bottom:66.6%;\">\n<img data-src=\"https:\/\/www.verywellhealth.com\/thmb\/NIZRWtVXh3fuqdQhgiGXBo70hc0=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/GettyImages-2258370616_4x3-e1eb2eb49cf44baba5384bb6a96e8823.jpg\" width=\"300\" height=\"200\" alt=\"A person applies a bandage to another persons upper arm in a pharmacy setting after a medical procedure\" class=\" universal-image__image lazyloadwait\"><br \/>\n<noscript><br \/>\n<img\nsrc=\"https:\/\/www.verywellhealth.com\/thmb\/NIZRWtVXh3fuqdQhgiGXBo70hc0=\/300x200\/filters:no_upscale():max_bytes(150000):strip_icc():format(webp)\/GettyImages-2258370616_4x3-e1eb2eb49cf44baba5384bb6a96e8823.jpg\"\nwidth=\"300\"\nheight=\"200\"\nclass=\"img--noscript universal-image__image\"\nalt=\"A person applies a bandage to another persons upper arm in a pharmacy setting after a medical procedure\"\n\/><br \/>\n<\/noscript>\n<\/div>\n<\/div>\n<\/div>\n<p><\/a><\/div>\n<\/div>\n<div id=\"mntl-sc-block_18-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-how-is-the-mrna-flu-shot-different-from-a-traditional-flu-shot\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_19-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> How Is the mRNA Flu Shot Different From a Traditional Flu Shot? <\/span> <\/h2>\n<p id=\"mntl-sc-block_20-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Commonly made using egg-based manufacturing, traditional flu vaccines introduce bits of influenza virus proteins into the body. This then trains the immune system to build a response that protects itself from the flu.<span data-cite=\"12\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_21-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_22-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The mFLUSIVA vaccine works by giving cells instructions to make the flu virus\u2019s surface protein, which teaches the immune system to recognize this protein and build antibodies against it. An mRNA vaccine can be updated more quickly to match circulating flu strains and may produce a stronger immune response against <a href=\"https:\/\/www.verywellhealth.com\/flu-a-vs-flu-b-7090660\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\">influenza A and B<\/a> than the traditional flu shot.<span data-cite=\"9\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_23-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_24-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> That could be especially important for older adults, who may not develop a strong enough immune response to existing flu vaccines, Ogbuagu said. Currently, flu vaccines vary drastically in effectiveness from year to year, reducing the risk of hospitalizations by 19%\u201360%.<span data-cite=\"10\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_25-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_26-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cThere\u2019s a need for a vaccine platform that also boosts seroresponse rates, where people are more likely to generate the protective antibody response,\u201d Ogbuagu said.\n<\/p>\n<div id=\"mntl-sc-block_27-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-what-are-the-side-effects\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_28-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> What Are the Side Effects? <\/span> <\/h2>\n<p id=\"mntl-sc-block_29-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> During the clinical trials, participants who received the mRNA vaccine reported <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/what-are-common-flu-shot-reactions-770528\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">side effects including pain at the injection site<\/a>, tiredness, headache, and muscle or joint pain.<span data-cite=\"13\" class=\"inline-citation-node\"><\/span> These reactions were relatively mild and similar to those associated with the standard flu shot.<span data-cite=\"14\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_30-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_31-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cRates of serious adverse events were quoted at 2.2% in those who got the mRNA vaccine, compared to 1.9% who got the standard dose vaccine,\u201d Wang said. \u201cThat\u2019s pretty low rates of serious adverse events in both groups.\u201d\n<\/p>\n<div id=\"mntl-sc-block_32-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_33-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Ogbuagu said that symptoms like headache and fatigue are just a marker that the body\u2019s immune system is responding to the vaccine.\n<\/p>\n<div id=\"mntl-sc-block_34-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_35-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cWe actually found in COVID vaccines, for example, that people who have more of those local symptoms tended to have higher immune responses,\u201d he added. <strong>\u201c<\/strong>And, of course, that\u2019s the best correlate for clinical protection that we have.\u201d\n<\/p>\n<div id=\"mntl-sc-block_36-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-when-will-it-be-available\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_37-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> When Will It Be Available? <\/span> <\/h2>\n<p id=\"mntl-sc-block_38-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Although Moderna says that the mFLUSIVA is expected to arrive for the 2026-2027 flu season,<span data-cite=\"2\" class=\"inline-citation-node\"><\/span> it has not been recommended<strong> <\/strong>by the Advisory Committee on Immunization Practices (ACIP), a medical expert panel at the CDC.\n<\/p>\n<div id=\"mntl-sc-block_39-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_40-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> ACIP recommendations allow vaccines to be covered by most insurance.<span data-cite=\"15\" class=\"inline-citation-node\"><\/span> It is not yet clear how much the new vaccine will cost out of pocket and whether insurers will cover it this year<strong>.<\/strong>\n<\/p>\n<div id=\"mntl-sc-block_41-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_42-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Wang doesn\u2019t expect mFLUSIVA to be widely available at pharmacies this year.\n<\/p>\n<div id=\"mntl-sc-block_43-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_44-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cMany hospitals are already creating their formularies for this respiratory season,\u201d she said. \u201cAt Dartmouth, we signed our contract for our flu vaccine back in February. I\u2019m curious to see how things unfold next season, and I think a number of things will drive that, including cost.\u201d\n<\/p>\n<div id=\"mntl-sc-block_45-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_46-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Wang encourages people to get their flu shots, regardless of whether mFLUSIVA is available. \u201cI want to make sure that people don\u2019t forget that it is currently a risk. Last year was a bad flu season,\u201d she said. \u201cThis year, I think, could also shape up that way.\u201d\n<\/p>\n<\/div>\n<div id=\"post-article_1-0\" class=\"comp post-article mntl-block\">\n<div id=\"breadcrumbs--chips_1-0\" class=\"comp breadcrumbs--chips mntl-universal-breadcrumbs--chips mntl-block\">\n<div id=\"mntl-breadcrumbs__read-more_1-0\" class=\"comp mntl-breadcrumbs__read-more mntl-text-block text-title-100\">Read More:<\/div>\n<ul id=\"mntl-universal-breadcrumbs_1-0\" class=\"comp mntl-universal-breadcrumbs mntl-block breadcrumbs\" data-tracking-container=\"true\">\n<li id=\"mntl-breadcrumbs__item_1-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/health-a-z-4014770\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_5-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Health A-Z<\/span><\/a><\/li>\n<li id=\"mntl-breadcrumbs__item_2-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/cold-flu-overview-4581986\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_6-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Cold &amp; Flu<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n<div id=\"sources_1-0\" class=\"comp sources mntl-block\">\n<div id=\"mntl-article-sources_1-0\" class=\"comp mntl-article-sources mntl-expandable-block\" data-scroll-offset=\"70\">\n<div class=\"loc toggle-content\">\n<div id=\"mntl-article-sources__wrapper_1-0\" class=\"comp mntl-article-sources__wrapper mntl-block\" data-click-tracked=\"true\" tabindex=\"0\"><span id=\"mntl-article-sources__heading_1-0\" class=\"comp mntl-article-sources__heading mntl-text-block\">11 Sources<\/span><br \/>\n<svg class=\"icon show-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#show-icon\" href=\"#show-icon\"><\/use>\n<\/svg><br \/>\n<svg class=\"icon hide-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#hide-icon\" href=\"#hide-icon\"><\/use>\n<\/svg><\/div>\n<\/div>\n<div class=\"loc expandable-content\">\n<div id=\"source-guidelines_1-0\" class=\"comp source-guidelines mntl-text-block\">Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our <a href=\"\/verywell-editorial-process-4777042\">editorial process<\/a> to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.<\/div>\n<div id=\"mntl-article-sources__citation-sources_1-0\" class=\"comp mntl-article-sources__citation-sources mntl-citation-sources mntl-sources\" data-tracking-container=\"true\">\n<ol class=\"mntl-sources__content\">\n<li class=\"mntl-sources__source\" id=\"citation-1\">\n<p>Li J, Liu Y, Dai J, et al. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12572956\/\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">mRNA vaccines: current applications and future directions<\/a>. <em>MedComm (2020)<\/em>. 2025;6(11):e70434. doi:10.1002\/mco2.70434<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-7\">\n<p>Leroux-Roels I, Huang G, Ferguson M, et al.<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2516491\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\"> Efficacy and safety of an mrna seasonal influenza vaccine in adults<\/a>. <em>N Engl J Med<\/em>. 2026;394(18):1803-1813. doi:10.1056\/NEJMoa2516491<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-8\">\n<p>ClinicalTrials.gov. <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05827978\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Study of mRNA-1010 seasonal influenza vaccine in adults (IGNITE P303)<\/a><\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-11\">\n<p>Soens M, Ananworanich J, Hicks B, et al. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0264410X25001446\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">A phase 3 randomized safety and immunogenicity trial of mRNA-1010 seasonal influenza vaccine in adults<\/a>. <em>Vaccine<\/em>. 2025;50:126847. doi:10.1016\/j.vaccine.2025.126847<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-12\">\n<p>Centers for Disease Control and Prevention. <a href=\"https:\/\/www.cdc.gov\/flu\/vaccine-process\/index.html\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">How influenza (flu) vaccines are made.<\/a><\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-9\">\n<p>Matz HC, Yu TG, Dixit K, et al. <a href=\"https:\/\/www.nature.com\/articles\/s41590-026-02569-5\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" rel=\"nofollow noopener\" target=\"_blank\">mRNA-based influenza vaccine expands the B cell response breadth in humans.<\/a> <em>Nat 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Clinical trials showed that mFLUSIVA was approximately 27% more effective than the standard flu shot. The mRNA technology allows scientists to match current flu&#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-63","post","type-post","status-publish","format-standard","hentry","category-chua-phan-loai"],"_links":{"self":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/63","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=63"}],"version-history":[{"count":0,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/63\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=63"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=63"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=63"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}