{"id":61,"date":"2026-11-06T09:06:25","date_gmt":"2026-11-06T09:06:25","guid":{"rendered":"https:\/\/healthcare.hibisports.com\/?p=61"},"modified":"2026-11-06T09:06:25","modified_gmt":"2026-11-06T09:06:25","slug":"you-can-soon-get-tylenol-and-naproxen-in-one-pill-for-longer-lasting-pain-relief","status":"publish","type":"post","link":"https:\/\/healthcare.hibisports.com\/?p=61","title":{"rendered":"You Can Soon Get Tylenol and Naproxen in One Pill for Longer-Lasting Pain Relief"},"content":{"rendered":"<div id=\"health-sc-page_1-0\" class=\"comp health-sc-page mntl-sc-page mntl-block structured-content article-content expert-content right-rail__offset lock-journey\" data-sc-sticky-offset=\"60\" data-sc-ad-label-height=\"24\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"4\" data-sc-content-positions=\"[400, 1400, 1400, 1700, 2000, 2200, 2400, 2600, 2800]\" data-bind-scroll-on-start=\"true\">\n<div id=\"health-sc-block-callout--key-takeaway_1-0\" class=\"comp health-sc-block-callout--key-takeaway health-sc-block-callout-base mntl-sc-block-callout mntl-block theme-key-takeaway theme-key-takeaway\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<h3 id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key Takeaways<\/h3>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block expert-content\">\n<ul>\n<li>Tylenol with Naproxen combines two common pain relievers into one pill to provide relief for minor aches and pains for up to 12 hours.<\/li>\n<li>The combination may be more effective than either medication alone.<\/li>\n<li>Because the medication contains both acetaminophen and naproxen, check other medicines you take to avoid accidentally exceeding the recommended dose.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Millions of Americans already reach for Tylenol to treat headaches, muscle pain, and fever. Now, a new over-the-counter option that combines Tylenol with the common pain reliever naproxen sodium will soon be available in pharmacies.<span data-cite=\"1\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_3-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-what-is-tylenol-with-naproxen\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> What Is Tylenol With Naproxen? <\/span> <\/h2>\n<p id=\"mntl-sc-block_5-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The new medication, <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/tramadol-and-aleve-5119155\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">Tylenol with Naproxen<\/a>, combines 325 milligrams of <a class=\"recommendation-inline-link\" href=\"https:\/\/www.verywellhealth.com\/acetaminophen-side-effects-11693509\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"2\" rel=\"noopener noreferrer\">acetaminophen<\/a> (Tylenol) and 110 mg of <a class=\"recommendation-inline-link\" href=\"https:\/\/www.verywellhealth.com\/naproxen-vs-ibuprofen-7093993\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"3\" rel=\"noopener noreferrer\">naproxen sodium<\/a> to provide up to 12 hours of pain relief. Standard Tylenol typically lasts four to six hours.<span data-cite=\"2\" class=\"inline-citation-node\"><\/span>\n<\/p>\n<div id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\">\n<div id=\"mm-ads-native_1-0\" class=\"comp mm-ads-native \" style=\"--native-ad-height: auto\" data-right-rail-index=\"1\">\n<div id=\"mm-ads-native__adunit_1-0\" class=\"comp mm-ads-native__adunit mm-ads-gpt-dynamic-adunit mm-ads-gpt-adunit scads-to-load gpt native js-immediate-ad js-immediate-ad-loaded\">\n<div id=\"native\" class=\"wrapper\" data-type=\"native\" data-pos=\"native\" data-priority=\"4\" data-sizes=\"[[1, 3],&quot;fluid&quot;]\" data-rtb=\"false\" data-wait-for-third-party=\"false\" data-targeting=\"{}\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_7-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> It\u2019s approved for adults and children ages 12 and older to treat minor aches and pains, including headaches, backaches, muscle aches, toothaches, menstrual cramps, and minor arthritis pain.\n<\/p>\n<div id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Although this product is new, taking acetaminophen and naproxen together is not, said <a href=\"https:\/\/www.ucsfhealth.org\/providers\/houston-williams\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Houston Williams, PharmD<\/a>, a pain management pharmacologist at UCSF Health. Healthcare providers have long recommended the two medications together because they relieve pain through different mechanisms.\n<\/p>\n<div id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_11-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> \u201cThe benefit is that the two medications can provide greater pain relief than either medication alone, without increasing the dose of either individual drug,\u201d Williams said.\n<\/p>\n<div id=\"mntl-sc-block_12-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The new product also offers added convenience by combining both medications into a single tablet with standardized dosing. \u201cFor some patients, that simplicity may improve adherence and make pain management easier,\u201d Williams said.\n<\/p>\n<div id=\"mntl-sc-block_14-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> He added that the combo is best suited for acute pain that also involves inflammation, such as an ankle sprain, pain after surgery, or burns. However, this treatment would not be effective for severe trauma, major surgery, or cancer-related pain.\n<\/p>\n<div id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p><span class=\"heading-toc\" id=\"toc-risks-and-side-effects-of-tylenol-with-naproxen\"><\/span><\/p>\n<h2 id=\"mntl-sc-block_17-0\" class=\"comp mntl-sc-block health-sc-block-heading mntl-sc-block-heading\"> <span class=\"mntl-sc-block-heading__text text-title-300\"> Risks and Side Effects of Tylenol With Naproxen <\/span> <\/h2>\n<p id=\"mntl-sc-block_18-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> The convenience comes with a trade-off. Fixed-dose combination products offer less flexibility than taking each medication separately. \u201cIf a patient only needs one medication or needs to adjust the dose of one but not the other, a combination product may be less ideal,\u201d Williams said.\n<\/p>\n<div id=\"mntl-sc-block_19-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_20-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> He noted that the biggest safety concern is that people may accidentally take another OTC or prescription medication that also contains acetaminophen or naproxen. Doing so could increase the risk of exceeding the recommended dose because many common medications already contain one of those ingredients.\n<\/p>\n<div id=\"mntl-sc-block_21-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_22-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> Although the combination medication is available over the counter, Williams said that doesn\u2019t mean it\u2019s risk-free. He recommends talking to a healthcare provider or pharmacist before taking it if you:\n<\/p>\n<div id=\"mntl-sc-block_23-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<ul id=\"mntl-sc-block_24-0\" class=\"comp mntl-sc-block mntl-sc-block-html\">\n<li>Have liver disease.<\/li>\n<li>Have kidney disease.<\/li>\n<li>Have a history of stomach ulcers or gastrointestinal bleeding.<\/li>\n<li>Take blood thinners.<\/li>\n<li>Have uncontrolled high blood pressure or heart disease.<\/li>\n<li>Are pregnant.<\/li>\n<\/ul>\n<div id=\"mntl-sc-block_25-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_26-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> If you\u2019re looking for pain relief on your own and haven\u2019t talked to a doctor, you can speak to a pharmacist about which pain reliever is most appropriate, said <a href=\"https:\/\/tcop.touro.edu\/about\/our-leadership\/michael-liu.php\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">Michael Liu, PharmD,<\/a>&nbsp;assistant dean of Clinical and Professional Affairs and Pharmacy Practice at the Touro College of Pharmacy in New York City.\n<\/p>\n<div id=\"mntl-sc-block_27-0\" class=\"comp mntl-sc-block mntl-sc-block-adslot mntl-block\"><\/div>\n<p id=\"mntl-sc-block_28-0\" class=\"comp mntl-sc-block mntl-sc-block-html\"> As a general rule of thumb, if you need to take <a class=\"recommendation-inline-link-ai\" href=\"https:\/\/www.verywellhealth.com\/nsaids-for-chronic-pain-2564481\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"internalLink\" data-ordinal=\"1\" rel=\"noopener noreferrer\">pain relievers for more than two weeks<\/a>, it could be a sign of an underlying condition that needs medical attention. \u201cAt that point, talking to your doctor or pharmacist is strongly recommended,\u201d Liu said.\n<\/p>\n<\/div>\n<div id=\"post-article_1-0\" class=\"comp post-article mntl-block\">\n<div id=\"breadcrumbs--chips_1-0\" class=\"comp breadcrumbs--chips mntl-universal-breadcrumbs--chips mntl-block\">\n<div id=\"mntl-breadcrumbs__read-more_1-0\" class=\"comp mntl-breadcrumbs__read-more mntl-text-block text-title-100\">Read More:<\/div>\n<ul id=\"mntl-universal-breadcrumbs_1-0\" class=\"comp mntl-universal-breadcrumbs mntl-block breadcrumbs\" data-tracking-container=\"true\">\n<li id=\"mntl-breadcrumbs__item_1-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/prevention-and-treatment-4158390\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_5-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Prevention &amp; Treatment<\/span><\/a><\/li>\n<li id=\"mntl-breadcrumbs__item_2-0\" class=\"comp mntl-breadcrumbs__item mntl-block text-utility-200\"><a href=\"https:\/\/www.verywellhealth.com\/prescription-and-otc-drugs-8640681\" rel=\"nocaes\" class=\"mntl-text-link mntl-breadcrumbs__link\" id=\"mntl-text-link_6-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Drugs<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n<div id=\"sources_1-0\" class=\"comp sources mntl-block\">\n<div id=\"mntl-article-sources_1-0\" class=\"comp mntl-article-sources mntl-expandable-block\" data-scroll-offset=\"70\">\n<div class=\"loc toggle-content\">\n<div id=\"mntl-article-sources__wrapper_1-0\" class=\"comp mntl-article-sources__wrapper mntl-block\" data-click-tracked=\"true\" tabindex=\"0\"><span id=\"mntl-article-sources__heading_1-0\" class=\"comp mntl-article-sources__heading mntl-text-block\">2 Sources<\/span><br \/>\n<svg class=\"icon show-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#show-icon\" href=\"#show-icon\"><\/use>\n<\/svg><br \/>\n<svg class=\"icon hide-icon \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#hide-icon\" href=\"#hide-icon\"><\/use>\n<\/svg><\/div>\n<\/div>\n<div class=\"loc expandable-content\">\n<div id=\"source-guidelines_1-0\" class=\"comp source-guidelines mntl-text-block\">Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our <a href=\"\/verywell-editorial-process-4777042\">editorial process<\/a> to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.<\/div>\n<div id=\"mntl-article-sources__citation-sources_1-0\" class=\"comp mntl-article-sources__citation-sources mntl-citation-sources mntl-sources\" data-tracking-container=\"true\">\n<ol class=\"mntl-sources__content\">\n<li class=\"mntl-sources__source\" id=\"citation-1\">\n<p>U.S. Food and Drug Administration. <a href=\"https:\/\/www.fda.gov\/drugs\/news-events-human-drugs\/fda-approves-first-nonprescription-fixed-dose-combination-acetaminophen-and-naproxen-sodium-12-hour\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" target=\"_blank\" rel=\"noopener\">FDA approves first nonprescription fixed-dose combination of acetaminophen and naproxen sodium for 12-hour pain relief<\/a>.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-2\">\n<p>Myers A, Gelotte C, Zuckerman A, et al. <a href=\"https:\/\/doi.org\/10.1080\/03007995.2023.2294946\" data-component=\"link\" data-source=\"inlineLink\" data-type=\"externalLink\" data-ordinal=\"1\" rel=\"noopener\" target=\"_blank\">Analgesic onset and efficacy of a fast-acting formulation of acetaminophen in a postoperative dental impaction pain model<\/a>.&nbsp;<em>Curr Med Res Opinion. <\/em>2024;40(2):267\u2013277. doi:10.1080\/03007995.2023.2294946<\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"author-bio_1-0\" class=\"comp author-bio bio--expanded\">\n<p class=\"author-bio__bio-text\">\n<span class=\"author-bio__bio-title\">By <a href=\"https:\/\/www.verywellhealth.com\/fran-kritz-5081944\">Fran Kritz<\/a><\/span><br \/>\n<br \/>\nKritz is a healthcare reporter with a focus on health policy. She is a former staff writer for U.S. News and World Report.\n<\/p>\n<\/div>\n<div id=\"trust-ribbon_1-0\" class=\"comp trust-ribbon trust-ribbon-expandable-block\">\n<div class=\"content-wrapper\">\n<div class=\"loc static-content\">\n<div id=\"trust-ribbon__editorial_1-0\" class=\"comp trust-ribbon__editorial trust-ribbon-item mntl-block\"><svg class=\"icon trust-ribbon-item__icon-editorial \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#trust-ribbon-item__icon-editorial\" href=\"#trust-ribbon-item__icon-editorial\"><\/use>\n<\/svg><br \/>\n<a href=\"\/verywell-editorial-process-4777042\" rel=\"nocaes\" class=\"trust-ribbon-item__text mntl-text-link \" id=\"trust-ribbon-item__text_1-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">See Our Editorial Process<\/span><\/a><\/div>\n<div id=\"trust-ribbon__review_1-0\" class=\"comp trust-ribbon__review trust-ribbon-item mntl-block\"><svg class=\"icon reviewer-icon trust-ribbon-item__icon-review\">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#reviewer-icon\" href=\"#reviewer-icon\"><\/use>\n<\/svg><br \/>\n<a href=\"\/meet-our-medical-expert-board-11762003\" rel=\"nocaes\" class=\"trust-ribbon-item__text mntl-text-link \" id=\"trust-ribbon-item__text_2-0\" data-tracking-container=\"true\"><span class=\"link__wrapper\">Meet Our Medical Expert Board<\/span><\/a><\/div>\n<\/div>\n<div class=\"loc toggle-content\">\n<div id=\"trust-ribbon__feedback_1-0\" class=\"comp trust-ribbon__feedback trust-ribbon-item mntl-block\"><svg class=\"icon trust-ribbon-item__icon-feedback \">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#trust-ribbon-item__icon-feedback\" href=\"#trust-ribbon-item__icon-feedback\"><\/use>\n<\/svg><br \/>\n<button id=\"trust-ribbon-item__text_3-0\" class=\"comp trust-ribbon-item__text mntl-text-block\">Share Feedback<\/button><\/div>\n<\/div><\/div>\n<div class=\"loc expandable-content\">\n<div id=\"trust-ribbon__feedback-block_1-0\" class=\"comp trust-ribbon__feedback-block article-feedback mntl-article-feedback\">\n<div class=\"article-feedback__rating-section js-rating-section is-hidden\">\n<div class=\"article-feedback__heading\">Was this page helpful?<\/div>\n<\/div>\n<div class=\"article-feedback__success-section js-success-section is-hidden\">\n<div class=\"article-feedback__heading\">Thanks for your feedback!<\/div>\n<\/div>\n<div class=\"article-feedback__feedback-section js-feedback-section\">\n<div class=\"article-feedback__heading\">What is your feedback?<\/div>\n<p><button id=\"helpful-button_1-0\" class=\"comp helpful-button mntl-button article-feedback__feedback-button\"> Helpful<br \/>\n<\/button><br \/>\n<button id=\"report-error-button_1-0\" class=\"comp report-error-button mntl-button article-feedback__feedback-button\"> Report an Error<br \/>\n<\/button><br \/>\n<button id=\"other-button_1-0\" class=\"comp other-button mntl-button article-feedback__feedback-button\"> Other<br \/>\n<\/button><br \/>\n<svg class=\"icon icon-x close-button\">\n<use xmlns_xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink_href=\"#icon-x\" href=\"#icon-x\"><\/use>\n<\/svg> <\/p>\n<form action=\"\/ugc-feedback\" method=\"post\" class=\"article-feedback__feedback-form js-feedback-form\">\n<textarea class=\"article-feedback__feedback-text js-feedback-text\" placeholder=\"Tell us more...\" required=\"required\" maxlength=\"1500\"><\/textarea><br \/>\n<button id=\"article-feedback__submit-button_1-0\" class=\"comp article-feedback__submit-button mntl-button\"> Submit<br \/>\n<\/button> <input type=\"hidden\" name=\"doc-id\" value=\"12026843\" class=\"js-doc-id\"><br \/>\n<\/form>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Key Takeaways Tylenol with Naproxen combines two common pain relievers into one pill to provide relief for minor aches and pains for up to 12 hours. The combination may be more effective than either medication alone. Because the medication contains&#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-61","post","type-post","status-publish","format-standard","hentry","category-chua-phan-loai"],"_links":{"self":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/61","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=61"}],"version-history":[{"count":0,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=\/wp\/v2\/posts\/61\/revisions"}],"wp:attachment":[{"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=61"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=61"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthcare.hibisports.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=61"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}